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Ripen NSENGA MD, Longxian CHENG PhD, Mei’an HE PhD, Tangchun WU PhD,
《医学前沿(英文)》 2009年 第3卷 第4期 页码 437-442 doi: 10.1007/s11684-009-0074-x
关键词: natriuretic peptide precursor A coronary heart disease gene polymorphism allelic discrimination polymorphism single nucleotide
Atomistic characterization of binding modes and affinity of peptide inhibitors to amyloid-
Fufeng LIU,Wenjie DU,Yan SUN,Jie ZHENG,Xiaoyan DONG
《化学科学与工程前沿(英文)》 2014年 第8卷 第4期 页码 433-444 doi: 10.1007/s11705-014-1454-6
关键词: Alzheimer’s disease amyloid β-protein peptide inhibitors protein-protein interaction molecular dynamics simulation
Cystine oligomers successfully attached to peptide cysteine-rich fibrils
Christian Bortolini,Mingdong Dong
《化学科学与工程前沿(英文)》 2016年 第10卷 第1期 页码 99-102 doi: 10.1007/s11705-016-1554-6
关键词: cysteine peptide fibrils gold nanoparticles amyloids oligomers nanomaterials
Glucagon-like peptide-2 exhibits protective effect on hepatic ischemia-reperfusion injury in rats
null
《医学前沿(英文)》 2015年 第9卷 第3期 页码 368-373 doi: 10.1007/s11684-015-0403-1
Glucagon-like peptide-2 (GLP-2) has potent anti-inflammatory effects and protects against experimental ischemia/reperfusion (I/R) injury in pulmonary, intestinal, and myocardial tissue. However, its protective abilities against I/R injury in the liver are unknown. We investigated the potential role of GLP-2 pretreatment on hepatic I/R injury in rats. A total of 24 rats were randomly divided into three groups (n = 8). The first group was the control group; the second group was the vehicle-treated hepatic ischemia/reperfusion (HIR, vehicle saline-treated) group; and the third group was the GLP-2 pretreated I/R (GLP2-IR) group. Each rat in the third group was intraperitoneally administered 5 μg GLP-2 for 5 d before the procedure. A portal triad was created to induce ischemia with a vascular atraumatic clamp. After 40 min, the clamp was released to initiate hepatic reperfusion for 6 h. Blood samples and tissue specimens from the liver were obtained. Alanine aminotransferase, aspartate aminotransferase, and total bilirubin levels significantly increased in the saline-treated HIR group (P<0.001), whereas GLP-2 pretreatment significantly decreased their levels (P<0.01). Our data suggested that GLP-2 pretreatment may have a protective effect on liver I/R injury. However, dose-response studies are necessary to determine the most effective dose.
关键词: ischemia/reperfusion liver glucagon-like peptide-2 alanine aminotransferase
Early T-cell precursor leukemia: a subtype of high risk childhood acute lymphoblastic leukemia
null
《医学前沿(英文)》 2012年 第6卷 第4期 页码 416-420 doi: 10.1007/s11684-012-0224-4
Acute lymphoblastic leukemia includes T-cell acute lymphoblastic leukemia (T-ALL) and B-cell acute lymphoblastic leukemia (B-ALL). In children, T-ALL usually has a worse prognosis than B-ALL, although childhood T-ALL prognoses have improved remarkably. The varying outcomes among T-ALL cases suggest that an unrecognized biological heterogeneity may contribute to chemo-resistance. Deep exploration of T-lymphocyte development in recent years has found a subgroup of patients with a phenotype that resembles early T-cell precursor, which confers a much poorer prognosis than any other form of T-ALL. This novel subtype of T-ALL was called early T-cell precursor acute lymphoblastic leukemia (ETP-ALL). Flow cytometry data from T-ALL patients enrolled in Shanghai Children’s Medical Center between July 2002 and October 2010 were assessed according to Dr. Campana’s protocol. Among total 89 T-ALL cases, 74 cases had enough immunophenotype data available to differentiate between ETP (CD1a-, CD8-, CD5dim, at least one marker of stem cell or myeloid lineage) and non-ETP. From these 74 subjects, 12 ETP-ALL cases (16.2%) were identified. The event-free survival (EFS) rate at 66.8 months was 11.1%±10.1% for ETP-ALL and 57.6%±5.6% for non-ETP-ALL (P=0.003). The overall survival rates were 13.3%±11.0% for ETP-ALL and 64.7%±6.3% for non-ETP-ALL (P=0.002). Our findings demonstrate that early T-cell precursor leukemia is a very high-risk subtype of acute lymphoblastic leukemia with poor prognosis.
关键词: acute lymphoblastic leukemia early T precursor prognosis
Carbon-coated lithium titanate: effect of carbon precursor addition processes on the electrochemical
Shilei Ding, Zelong Jiang, Jing Gu, Hongliang Zhang, Jiajia Cai, Dongdong Wang
《化学科学与工程前沿(英文)》 2021年 第15卷 第1期 页码 148-155 doi: 10.1007/s11705-020-2022-x
关键词: lithium titanate carbon-coated carbon precursor synthetic process
Huining HE, Junxiao YE, Jianyong SHENG, Jianxin WANG, Yongzhuo HUANG, Guanyi CHEN, Jingkang WANG, Victor C YANG
《化学科学与工程前沿(英文)》 2013年 第7卷 第1期 页码 9-19 doi: 10.1007/s11705-013-1306-9
关键词: insulin cell penetrating peptide mucoadhesive composites oral delivery
Rational Design of and Mechanism Insight into an Efficient Antifreeze Peptide for Cryopreservation
Haishan Qi,Yihang Gao,Lin Zhang,Zhongxin Cui,Xiaojie Sui,Jianfan Ma,Jing Yang,Zhiquan Shu,Lei Zhang,
《工程(英文)》 doi: 10.1016/j.eng.2023.01.015
关键词: Antifreeze peptides Evolution analysis Ice recrystallization inhibition Molecular dynamics simulation Cryopreservation Synthetic biology
W. Widiyastuti, Adhi Setiawan, Sugeng Winardi, Tantular Nurtono, Heru Setyawan
《化学科学与工程前沿(英文)》 2014年 第8卷 第1期 页码 104-113 doi: 10.1007/s11705-014-1406-1
关键词: droplet hydroxyapatite particle CFD tubular furnace spray pyrolysis
电中性固体表面上多条肽链的吸附过程——粗粒化模拟研究 Research
裘若桑, 肖杰, 陈晓东
《工程(英文)》 2020年 第6卷 第2期 页码 185-194 doi: 10.1016/j.eng.2018.12.012
蛋白质在固体表面的吸附过程涉及诸多复杂的分子间相互作用,因此到目前为止仍然无法做到精准调控。通过模拟计算,可以获取固-液界面分子尺度的蛋白质移动机理,从而为预测蛋白质吸附和结垢现象提供可靠的理论依据。本研究通过多尺度粗粒化模型对多条疏水的丙氨酸十二肽在金表面的聚集和吸附过程进行了分析。大约有一半(46.6%)的丙氨酸十二肽可以组成聚集体。30.0%的独立肽链会被快速地吸附到固体表面。这些在表面吸附的肽链经过一段时间的爬行,其中的一些(51.0%)能与吸附在表面的或是游离在溶液中的肽链融合,从而形成吸附在表面的聚集体。这些在固-液界面吸附的肽链使得固体表面性质发生变化。这一变化可能会进一步影响之后溶液中肽链和聚集体在金表面的吸附。本研究揭示的多条肽链吸附机理有希望为进一步研究多个蛋白质分子在固体表面的吸附机理提供理论基础。
Emerging molecular subtypes and therapeutic targets in B-cell precursor acute lymphoblastic leukemia
Jianfeng Li, Yuting Dai, Liang Wu, Ming Zhang, Wen Ouyang, Jinyan Huang, Saijuan Chen
《医学前沿(英文)》 2021年 第15卷 第3期 页码 347-371 doi: 10.1007/s11684-020-0821-6
关键词: BCP-ALL subtypes translocation aneuploidy sequence mutations
Xinghong Duo, Lingchuang Bai, Jun Wang, Jintang Guo, Xiangkui Ren, Shihai Xia, Wencheng Zhang, Abraham Domb, Yakai Feng
《化学科学与工程前沿(英文)》 2020年 第14卷 第5期 页码 889-901 doi: 10.1007/s11705-020-1919-8
关键词: gene carriers multitargeting function ECs transfection efficiency
Hydrothermal synthesis of crystalline α-/β-MnO2 nanorods via γ-MnOOH nanorod precursors
ZHANG Weixin, REN Xiangbin, YANG Zeheng, WANG Hua, WANG Qiang, HUANG Fei
《化学科学与工程前沿(英文)》 2007年 第1卷 第4期 页码 365-371 doi: 10.1007/s11705-007-0066-9
关键词: obtained -MnOOH precursor Besides high-resolution transmission precursor
Xinghong Duo, Lingchuang Bai, Jun Wang, Jintang Guo, Xiangkui Ren, Shihai Xia, Wencheng Zhang, Abraham Domb, Yakai Feng
《化学科学与工程前沿(英文)》 2021年 第15卷 第1期 页码 220-220 doi: 10.1007/s11705-020-1995-9
Precursor-driven structural tailoring of iron oxychloride for enhanced heterogeneous Fenton activity
《化学科学与工程前沿(英文)》 2023年 第17卷 第10期 页码 1533-1543 doi: 10.1007/s11705-023-2330-z
关键词: FeOCl mechanical activation heterogeneous Fenton reaction ball milling
标题 作者 时间 类型 操作
The role of natriuretic peptide precursor A gene polymorphism in the development of coronary heart disease
Ripen NSENGA MD, Longxian CHENG PhD, Mei’an HE PhD, Tangchun WU PhD,
期刊论文
Atomistic characterization of binding modes and affinity of peptide inhibitors to amyloid-
Fufeng LIU,Wenjie DU,Yan SUN,Jie ZHENG,Xiaoyan DONG
期刊论文
Cystine oligomers successfully attached to peptide cysteine-rich fibrils
Christian Bortolini,Mingdong Dong
期刊论文
Glucagon-like peptide-2 exhibits protective effect on hepatic ischemia-reperfusion injury in rats
null
期刊论文
Early T-cell precursor leukemia: a subtype of high risk childhood acute lymphoblastic leukemia
null
期刊论文
Carbon-coated lithium titanate: effect of carbon precursor addition processes on the electrochemical
Shilei Ding, Zelong Jiang, Jing Gu, Hongliang Zhang, Jiajia Cai, Dongdong Wang
期刊论文
Overcoming oral insulin delivery barriers: application of cell penetrating peptide and silica-based nanoporous
Huining HE, Junxiao YE, Jianyong SHENG, Jianxin WANG, Yongzhuo HUANG, Guanyi CHEN, Jingkang WANG, Victor C YANG
期刊论文
Rational Design of and Mechanism Insight into an Efficient Antifreeze Peptide for Cryopreservation
Haishan Qi,Yihang Gao,Lin Zhang,Zhongxin Cui,Xiaojie Sui,Jianfan Ma,Jing Yang,Zhiquan Shu,Lei Zhang,
期刊论文
Particle formation of hydroxyapatite precursor containing two components in a spray pyrolysis process
W. Widiyastuti, Adhi Setiawan, Sugeng Winardi, Tantular Nurtono, Heru Setyawan
期刊论文
Emerging molecular subtypes and therapeutic targets in B-cell precursor acute lymphoblastic leukemia
Jianfeng Li, Yuting Dai, Liang Wu, Ming Zhang, Wen Ouyang, Jinyan Huang, Saijuan Chen
期刊论文
Multifunctional peptide conjugated amphiphilic cationic copolymer for enhancing ECs targeting, penetrating
Xinghong Duo, Lingchuang Bai, Jun Wang, Jintang Guo, Xiangkui Ren, Shihai Xia, Wencheng Zhang, Abraham Domb, Yakai Feng
期刊论文
Hydrothermal synthesis of crystalline α-/β-MnO2 nanorods via γ-MnOOH nanorod precursors
ZHANG Weixin, REN Xiangbin, YANG Zeheng, WANG Hua, WANG Qiang, HUANG Fei
期刊论文
Erratum to: Multifunctional peptide conjugated amphiphilic cationic copolymer for enhancing ECs targeting
Xinghong Duo, Lingchuang Bai, Jun Wang, Jintang Guo, Xiangkui Ren, Shihai Xia, Wencheng Zhang, Abraham Domb, Yakai Feng
期刊论文